When a man is sexually aroused, nitric oxide is released in the erectile tissue of the penis, activating an enzyme that produces cyclic guanosine monophosphate (cGMP). This compound relaxes the smooth muscles, allowing blood to flow into the penile arteries, resulting in an erection. However, PDE5 enzymes can degrade cGMP, leading to the loss of erection. Kamagra Oral Jelly inhibits PDE5, allowing cGMP to accumulate and sustain an erection.